Fawcett, who rose to fame as the star of U.S television's "Charlie's Angels," was first diagnosed with anal cancer in late 2006.
She passed away at 9:28 a.m. PT at St. John's Hospital in Santa Monica.
Her longtime partner Ryan O'Neal was at her bedside.
In a statement O'Neal said: "After a long and brave battle with cancer, our beloved Farrah has passed away. Although this is an extremely difficult time for her family and friends, we take comfort in the beautiful times that we shared with Farrah over the years and the knowledge that her life brought joy to so many people around the world."
Couple of people some of us grew up watching....Gone!